I narrowed the choice to Tkinter and wxPython fairly quickly--based on Tkinter being the de facto alternative and wxPython being the most discussed alternative on a basic Google search of "Python GUI".
Also wxPython has the largest widget collection, including a spreadsheet and since what I'm doing will involve a spreadsheet-like interface I decided that further investigation had quickly diminishing returns.
PyQt looks very powerful, and drives the incredibly impressive Orange application--but failed the "can I install and use it without much brain damage?" test, as did pyGTK (also known as the "can an idiot install it?" test--me being the idiot--if something requires more than one or steps to install, it generally fails this test). I would not be surprised to need revisit pyQt and pyGTK for larger scale projects.
The following, very helpful discussion walks through a very simple app in Tkinter and wxPython side-by-side. Good for understanding the basic differences of the two packages and for understand the basics of GUI programming.
Building a basic GUI application in Python with Tkinter and wxWidgets
NB: One fact that might help clear confusion as you surf GUI related posts-- wxWidgets == wxWindows. The name of the underlying C++ library was changed to wxWidgets at some point (no doubt copyright/trademark related).
I'm also starting to look at wxGlade, a GUI builder wrapper for wxPython.
NB, re Editors: I am using Eclipse with Pydev, with good results.

Also wxPython has the largest widget collection, including a spreadsheet and since what I'm doing will involve a spreadsheet-like interface I decided that further investigation had quickly diminishing returns.
PyQt looks very powerful, and drives the incredibly impressive Orange application--but failed the "can I install and use it without much brain damage?" test, as did pyGTK (also known as the "can an idiot install it?" test--me being the idiot--if something requires more than one or steps to install, it generally fails this test). I would not be surprised to need revisit pyQt and pyGTK for larger scale projects.
The following, very helpful discussion walks through a very simple app in Tkinter and wxPython side-by-side. Good for understanding the basic differences of the two packages and for understand the basics of GUI programming.
Building a basic GUI application in Python with Tkinter and wxWidgets
NB: One fact that might help clear confusion as you surf GUI related posts-- wxWidgets == wxWindows. The name of the underlying C++ library was changed to wxWidgets at some point (no doubt copyright/trademark related).
I'm also starting to look at wxGlade, a GUI builder wrapper for wxPython.
NB, re Editors: I am using Eclipse with Pydev, with good results.

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